Modulation of central muscarinic receptor binding in vitro by ultralow levels of the organophosphate paraoxon.

@article{Katz1989ModulationOC,
  title={Modulation of central muscarinic receptor binding in vitro by ultralow levels of the organophosphate paraoxon.},
  author={Lawrence S. Katz and Judith K. Marquis},
  journal={Toxicology and applied pharmacology},
  year={1989},
  volume={101 1},
  pages={114-23}
}
Homogenates of calf caudate nuclei were found to contain at least three distinct subclasses of cholinergic, muscarinic receptors. These subtypes, labeled with [3H]quinuclidinyl benzilate (QNB), can be separated by rapid filtration with the use of the selective ligands, pirenzepine, AF-DX116, and 4-DAMP which have high affinity for the M1, M2, and M3 subtypes, respectively. Paraoxon was found to modulate [3H]QNB binding in a noncompetitive manner at concentrations below those needed to affect… CONTINUE READING

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