Modulation of cellular susceptibility to the cytotoxic/cytostatic action of tumor necrosis factor by adenovirus E1 gene expression is cell type-dependent.

@article{Vanhaesebroeck1990ModulationOC,
  title={Modulation of cellular susceptibility to the cytotoxic/cytostatic action of tumor necrosis factor by adenovirus E1 gene expression is cell type-dependent.},
  author={Bart Vanhaesebroeck and H Th Marc Timmers and G. J. Pronk and Frans van Roy and Alex J. van der Eb and Walter Fiers},
  journal={Virology},
  year={1990},
  volume={176 2},
  pages={
          362-8
        }
}
Primary baby rat kidney cells, primary human embryonic retinoblast cells, established NIH3T3 and established normal rat kidney (NRK) cells, expressing E1A and/or E1B gene regions of adenovirus 5 (Ad5) or Ad12, were investigated for susceptibility to the cytotoxic/cytostatic action of Tumor Necrosis Factor (TNF). In the primary cells and in the NRK cells, there was no correlation between TNF sensitivity and E1 gene expression; neither did sensitivity to TNF correlate with the oncogenicity of the… CONTINUE READING
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