Modulation of cellular signaling by herpesvirus-encoded G protein-coupled receptors

  title={Modulation of cellular signaling by herpesvirus-encoded G protein-coupled receptors},
  author={Sabrina M. de Munnik and Martine J. Smit and Rob Leurs and Henry F. Vischer},
  booktitle={Front. Pharmacol.},
Human herpesviruses (HHVs) are widespread infectious pathogens that have been associated with proliferative and inflammatory diseases. During viral evolution, HHVs have pirated genes encoding viral G protein-coupled receptors (vGPCRs), which are expressed on infected host cells. These vGPCRs show highest homology to human chemokine receptors, which play a key role in the immune system. Importantly, vGPCRs have acquired unique properties such as constitutive activity and the ability to bind a… CONTINUE READING
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