Modulation of cell-fibronectin matrix interactions during tissue repair.

  title={Modulation of cell-fibronectin matrix interactions during tissue repair.},
  author={Kim S. Midwood and Yong Mao and Henry C. Hsia and Leyla V Valenick and Jean E. Schwarzbauer},
  journal={The journal of investigative dermatology. Symposium proceedings},
  volume={11 1},
Environmental signals from the extracellular matrix (ECM) are transmitted by cell surface receptors that connect to the actin cytoskeleton and to multiple intracellular signaling pathways. To dissect how the ECM regulates cell functions, we are using a three-dimensional (3D) fibrin-fibronectin matrix, resembling the wound provisional matrix. Fibroblasts adhere to fibronectin in this matrix via concomitant engagement of alpha 5 beta 1 integrin receptors and syndecan-4, a transmembrane… CONTINUE READING


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