Modulation of cell death in yeast by the Bcl-2 family of proteins.

  title={Modulation of cell death in yeast by the Bcl-2 family of proteins.},
  author={Wen Tao and Cornelia Kurschner and J. I. Morgan},
  journal={The Journal of biological chemistry},
  volume={272 24},
Bcl-2 family members are regulators of cell death. The precise biochemical properties of these proteins are unclear although intrafamily protein-protein association is thought to be involved. To elucidate structure-activity relationships among Bcl-2 proteins and identify the pathways in which they act, an inducible death suppressor assay was developed in yeast. Only Bax and Bak killed yeast via a process that did not require interleukin-1beta-converting enzyme-like proteases. Bax/Bak lethality… CONTINUE READING

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