Modulation of cell cycles and apoptosis by apicidin in estrogen receptor (ER)-positive and-negative human breast cancer cells.

@article{Im2008ModulationOC,
  title={Modulation of cell cycles and apoptosis by apicidin in estrogen receptor (ER)-positive and-negative human breast cancer cells.},
  author={Ji Young Im and Hyeyoung Park and Keon Wook Kang and Wahn Soo Choi and Hyung Sik Kim},
  journal={Chemico-biological interactions},
  year={2008},
  volume={172 3},
  pages={235-44}
}
The histone deacetylase (HDAC) inhibitor, apicidin, has been shown to suppress the growth of human breast cancer cells. In this article, we examined the ability of apicidin to inhibit the proliferation of human breast cancer cell lines. Cell cycle regulators and apoptotic cell death were determined using Western blot analysis and DAPI fluorescence staining… CONTINUE READING