Modulation of cell cycle progression and of antibody production in mouse hybridomas by a nucleotide analogue

@article{Franek1998ModulationOC,
  title={Modulation of cell cycle progression and of antibody production in mouse hybridomas by a nucleotide analogue},
  author={Frantisek Franek and Anton{\'i}n Hol{\'y} and Ivan Votruba and Tomas Eckschlager},
  journal={Cytotechnology},
  year={1998},
  volume={28},
  pages={65-72}
}
The nucleotide analogue 9-[2-(phosphonomethoxy)ethyl]guanine (PMEG) has been identified as a powerful antiproliferative substance when acting on hybridoma cells. In the range of 10 nM to 100 nM concentrations this agent reduces cell growth rate, while its apoptosis-inducing activity is marginal. Marked induction of apoptosis can be observed at micromolar and higher order concentrations. In PMEG-supplemented media the cell cycle progression is perturbed, the flow-cytometric DNA profile shows a… CONTINUE READING

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