Modulation of cardiac sodium channels by cAMP receptors on the myocyte surface.

@article{Sorbera1991ModulationOC,
  title={Modulation of cardiac sodium channels by cAMP receptors on the myocyte surface.},
  author={L A Sorbera and Martin Morad},
  journal={Science},
  year={1991},
  volume={253 5025},
  pages={1286-9}
}
The phosphorylation of the cardiac sodium channel by adenosine 3',5'-monophosphate (cAMP)-dependent protein kinase A leads to its inactivation. It was shown that extracellular cAMP can also modulate the sodium channel of rat, guinea pig, and frog ventricular myocytes in a rapid (less than 50 milliseconds), reversible, and dose-dependent manner. The decrease in the sodium current was accompanied by a 10- to 15-millivolt shift in the steady-state availability of the sodium channel toward more… CONTINUE READING

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