• DOI:10.1177/0748233713485885
• Corpus ID: 25066675

Modulation of carbon tetrachloride-induced nephrotoxicity in rats by n-hexane extract of Sonchus asper

@article{Khan2015ModulationOC,
  title={Modulation of carbon tetrachloride-induced nephrotoxicity in rats by n-hexane extract of Sonchus asper},
  author={Rahmat Ali Khan and Muhammad Rashid Khan and Naseer Ali Shah and Sumaira Sahreen and Pakiza Siddiq},
  journal={Toxicology and Industrial Health},
  year={2015},
  volume={31},
  pages={955 - 959}
}

• R. Khan, Muhammad Rashid Khan, +2 authors Pakiza Siddiq
• Published 1 October 2015
• Biology, Chemistry
• Toxicology and Industrial Health

Sonchus asper is traditionally used in the treatment of renal dysfunction. In the present study, protective effects of S. asper against carbon tetrachloride (CCl4)-induced nephrotoxicity of rats were determined. In this study, 24 male albino rats (190–200 g) were equally divided into four groups. Group I (control group) was given saline (1 ml/kg body weight (b.w.), 0.85% NaCl) and dimethyl sulfoxide (1 ml/kg b.w.); group II was treated with CCl4 (1 ml/kg b.w. intraperitoneally); groups III and IV were administered with CCl4 and after 48 h with S. asper n-hexane extract (SHE; 100 and 200 mg/kg b.w.). All the treatments were given twice a week for 4 weeks. The results revealed that CCl4-induced oxidative stress as evidenced by the significant depletion of antioxidant enzymes, namely, superoxide dismutase, catalase, peroxidase, glutathione-S-transferase, glutathione peroxidase, glutathione reductase, and glutathione contents, while increased lipid peroxidation (thiobarbituric acid-reactive substances contents). Administration of SHE significantly ameliorated (p < 0.01) the activity of antioxidant enzymes and reduced lipid peroxides. Coadministration revealed that S. asper extract can protect the kidney against CCl4-mediated oxidative damage by restoring the activity of antioxidant enzyme, due to the presence of plant bioactive constituents.