Modulation of camptothecin analogs in the treatment of cancer: a review.

@article{Kehrer2001ModulationOC,
  title={Modulation of camptothecin analogs in the treatment of cancer: a review.},
  author={Diederik F S Kehrer and Otto Soepenberg and Walter J. Loos and Jaap Verweij and Alex Sparreboom},
  journal={Anti-cancer drugs},
  year={2001},
  volume={12 2},
  pages={89-105}
}
The topoisomerase I inhibitors reviewed in this paper are all semisynthetic analogs of camptothecin (CPT). Modulation of this intranuclear enzyme translates clinically in to antitumor activity against a broad spectrum of tumors and is therefore the subject of numerous investigations. We present preclinical and clinical data on CPT analogs that are already being used in clinical practice [i.e. topotecan and irinotecan (CPT-11)] or are currently in clinical development (e.g. 9-aminocamptothecin… CONTINUE READING