Modulation of calmodulin plasticity in molecular recognition on the basis of x-ray structures.

@article{Meador1993ModulationOC,
  title={Modulation of calmodulin plasticity in molecular recognition on the basis of x-ray structures.},
  author={William E. Meador and Anthony R. Means and Florante A. Quiocho},
  journal={Science},
  year={1993},
  volume={262 5140},
  pages={1718-21}
}
Calmodulin is the primary calcium-dependent signal transducer and regulator of a wide variety of essential cellular functions. The structure of calcium-calmodulin bound to the peptide corresponding to the calmodulin-binding domain of brain calmodulin-dependent protein kinase II alpha was determined to 2 angstrom resolution. A comparison to two other calcium-calmodulin structures reveals how the central helix unwinds in order to position the two domains optimally in the recognition of different… CONTINUE READING
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