Modulation of calcium signalling by mitochondria.

  title={Modulation of calcium signalling by mitochondria.},
  author={Ciara M. Walsh and Stephanie L. Barrow and Svetlana Voronina and Michael Chvanov and Ole H Petersen and Alexei V Tepikin},
  journal={Biochimica et biophysica acta},
  volume={1787 11},
In this review we will attempt to summarise the complex and sometimes contradictory effects that mitochondria have on different forms of calcium signalling. Mitochondria can influence Ca(2+) signalling indirectly by changing the concentration of ATP, NAD(P)H, pyruvate and reactive oxygen species - which in turn modulate components of the Ca(2+) signalling machinery i.e. buffering, release from internal stores, influx from the extracellular solution, uptake into cellular organelles and extrusion… CONTINUE READING


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