Modulation of calcium oxalate monohydrate crystallization by citrate through selective binding to atomic steps.

@article{Qiu2005ModulationOC,
  title={Modulation of calcium oxalate monohydrate crystallization by citrate through selective binding to atomic steps.},
  author={S. Roger Qiu and Andrzej Wierzbicki and Edward A. Salter and Salvador Zepeda and Chris A Orme and John R. Hoyer and George H. Nancollas and Anita M. Cody and James J De Yoreo},
  journal={Journal of the American Chemical Society},
  year={2005},
  volume={127 25},
  pages={9036-44}
}
The majority of human kidney stones are composed primarily of calcium oxalate monohydrate (COM) crystals. Thus, determining the molecular modulation of COM crystallization by urinary constituents is crucial for understanding and controlling renal stone disease. A comprehensive molecular-scale view of COM shape modification by citrate, obtained through a combination of in situ atomic force microscopy and molecular modeling, is presented here. We find that while the most important factors… CONTINUE READING