Modulation of calcium-currents by capsaicin in a subpopulation of sensory neurones of guinea pig

  title={Modulation of calcium-currents by capsaicin in a subpopulation of sensory neurones of guinea pig},
  author={Marlen Petersen and G. Wagner and Fr.-K. Pierau},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
SummaryThe action of capsaicin (CAP) on the total Ca2+ current was examined in internally perfused voltage-clamped dorsal root ganglion (DRG) neurones of guinea pigs. CAP changed the total Ca2+ current in about 50% of the investigated DRG neurones (“CAP-sensitive” neurones) in the following way: (I) a transient increase of the current amplitude at potentials between − 35 mV and about – 10 mV was accompanied by a shift of the current-voltage relation towards negative potentials by 5–8 mV; (II… 

Molecular Properties of Voltage-Gated Calcium Channels

Native Voltage-Gated Ca Channels Early electrophysiological recordings from neurons, muscle and endocrine cells revealed voltage-activated calcium (Ca) currents with distinct characteristics,

Block effect of capsaicin on hERG potassium currents is enhanced by S6 mutation at Y652.

Nicotine inhibits voltage-dependent sodium channels and sensitizes vanilloid receptors.

Several new effects of nicotine on channels involved in nociception are document and indicate how they may impact physiological processes involving pain and gustation.

Eugenol Inhibits Sodium Currents in Dental Afferent Neurons

Eugenol inhibits I Na in a TRPV1-independent manner and it is suggested that I Na inhibition by eugenol contributes to its analgesic effect.

Capsaicin-induced endocytosis of endogenous presynaptic CaV2.2 in DRG-spinal cord co-cultures inhibits presynaptic function

Data suggest that capsaicin causes a decrease in cell surface CaV2.2_HA expression in DRG terminals via a Rab11a-dependent endosomal trafficking pathway, which is key to neurotransmission from the primary afferent terminals of dorsal root ganglion neurons to their post-synaptic targets in the spinal cord.

Expression and Regulation of Cav3.2 T-Type Calcium Channels during Inflammatory Hyperalgesia in Mouse Dorsal Root Ganglion Neurons

Data suggest that Cav3.2 T-type channels participate in the development of inflammatory hyperalgesia, and this channel might play an even greater role in the sub-acute phase of inflammatory pain due to increased co-localization with TRPV1 receptors compared with that in the normal state.

Eugenol Inhibits Calcium Currents in Dental Afferent Neurons

The results suggest that the HVACC inhibition by eugenol in dental primary afferent neurons, which is not mediated by TRPV1 activation, might contribute to e Eugenol’s analgesic effect.

T-Type Calcium Channels: A Mixed Blessing

The relevance of T-type calcium channels in cancer and in chemotherapy side effects is put into context, considering also the cardiotoxicity induced by new classes of antineoplastic molecules.

Change in Cav3.2 T-Type Calcium Channel Induced by Varicella-Zoster Virus Participates in the Maintenance of Herpetic Neuralgia

A model for zoster-associated pain through varicella-zoster virus (VZV) infections of mouse footpads and pain behavior assessments is constructed, indicating that VZV might participate in the occurrence and development of HN by upregulating the expression of Cav3.2 in DRG and SDH.



The influence of capsaicin on membrane currents in dorsal root ganglion neurones of guinea-pig and chicken

The effect of capsaicin on voltage-dependent membrane currents of isolated dorsal root ganglia (DRG) neurones of guinea-pig and chicken were investigated by the voltage-clamp technique and

A low voltage-activated calcium conductance in embryonic chick sensory neurons.

Activation of a muscarinic receptor selectively inhibits a rapidly inactivated Ca2+ current in rat sympathetic neurons.

Muscarinic modulation of the N-type Ca2+ channels appears to be mediated by a pertussis toxin-sensitive guanine nucleotide-binding protein and independent of both cAMP-dependentprotein kinase and protein kinase C.

Depolarization elicits two distinct calcium currents in vertebrate sensory neurones

The calcium currents of rat sensory neurones (of the IX and X cranial nerves) grown in culture were studied using whole cell recordings and Ba was shown to act as a substitute with a lower affinity than Ca.

Effect of menthol on two types of Ca currents in cultured sensory neurons of vertebrates

The findings are consistent with the idea that menthol acts on two types of Ca channels coexisting on the membrane of cultured sensory neurons, and facilitates inactivation gating of the classical high voltage-activated Ca channel.

Depolarizing responses to capsaicin in a subpopulation of rat dorsal root ganglion cells

A low voltage-activated, fully inactivating Ca channel in vertebrate sensory neurones

Evidence is presented for a new type of Ca channel with time- and voltage-dependent properties which is probably responsible for the inactivation behaviour of the Ca conductance and coexists in isolated membrane patches with the more common Ca channel4 which shows a considerably shorter average life time and smaller currents.

Two types of calcium channels in the somatic membrane of new‐born rat dorsal root ganglion neurones.

The inactivation of the slow Ca2+ current studied in double‐pulse experiments was current‐dependent and developed very slowly (time constant of several hundreds of milliseconds), it slowed down even more at low temperature or after substitution of Ba2+ for Ca2- in the extracellular solution.

Dynorphin A selectively reduces a large transient (N-type) calcium current of mouse dorsal root ganglion neurons in cell culture.

  • R. GrossR. Macdonald
  • Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 1987
The results suggest a mechanism by which dynorphin A inhibits calcium influx and neurotransmitter release in DRG neurons, if N calcium channels are present in primary afferent terminals, and if they are coupled to kappa-opioid receptors as in the soma.