Modulation of calcium-activated potassium channels induces cardiogenesis of pluripotent stem cells and enrichment of pacemaker-like cells.

@article{Kleger2010ModulationOC,
  title={Modulation of calcium-activated potassium channels induces cardiogenesis of pluripotent stem cells and enrichment of pacemaker-like cells.},
  author={Alexander Kleger and Thomas Seufferlein and Daniela Malan and Michael Tischendorf and Alexander Storch and Anne Wolheim and Stephan Latz and Stephanie Protze and Marc Porzner and Christian Proepper and Cornelia Brunner and Sarah-Fee Katz and Ganesh Varma Pusapati and Lars Bullinger and Wolfgang Michael Franz and Ralf Koehntop and Klaudia Giehl and Andreas Spyrantis and Oliver H Wittekindt and Qiong Lin and Martin Zenke and Bernd K Fleischmann and Maria Wartenberg and Anna M. Wobus and Tobias Maria Boeckers and Stefan Liebau},
  journal={Circulation},
  year={2010},
  volume={122 18},
  pages={1823-36}
}
BACKGROUND Ion channels are key determinants for the function of excitable cells, but little is known about their role and involvement during cardiac development. Earlier work identified Ca(2+)-activated potassium channels of small and intermediate conductance (SKCas) as important regulators of neural stem cell fate. Here we have investigated their impact on the differentiation of pluripotent cells toward the cardiac lineage. METHODS AND RESULTS We have applied the SKCa activator 1-ethyl-2… CONTINUE READING