Modulation of calcification of vascular smooth muscle cells in culture by calcium antagonists, statins, and their combination

@article{Trion2007ModulationOC,
  title={Modulation of calcification of vascular smooth muscle cells in culture by calcium antagonists, statins, and their combination},
  author={Astrid Trion and Cindy Schutte-Bart and Wilhelmina H. Bax and Johan Wouter Jukema and Arnoud Van der Laarse},
  journal={Molecular and Cellular Biochemistry},
  year={2007},
  volume={308},
  pages={25 - 33}
}
Background Vascular calcification is an organized process in which vascular smooth muscle cells (VSMCs) are implicated primarily. The purpose of the present study was to assess the effects of calcium antagonists and statins on VSMC calcification in vitro. Methods VSMC calcification was stimulated by incubation in growth medium supplemented with 10 mmol/l β-glycerophosphate, 8 mmol/l CaCl2, 10 mmol/l sodium pyruvate, 1 μmol/l insulin, 50 μg/ml ascorbic acid, and 100 nmol/l dexamethasone… 
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Deletion of IκB‐Kinase β in Smooth Muscle Cells Induces Vascular Calcification Through β‐Catenin–Runt‐Related Transcription Factor 2 Signaling
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IKKβ negatively regulates VSMC calcification through β‐catenin–Runt‐related transcription factor 2 signaling, which revealed a novel function of IKKβ on vascular calcification.
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