Modulation of brain tumor capillaries for enhanced drug delivery selectively to brain tumor.

  title={Modulation of brain tumor capillaries for enhanced drug delivery selectively to brain tumor.},
  author={Keith L. Black and Nagendra S. Ningaraj},
  journal={Cancer control : journal of the Moffitt Cancer Center},
  volume={11 3},
BACKGROUND The blood-brain tumor barrier (BTB) significantly impedes delivery of most hydrophilic molecules to brain tumors. Several promising strategies, however, have been developed to overcome this problem. METHODS We discuss several drug delivery methods to brain tumor, including intracerebroventricular, convection enhanced delivery, BBB/BTB disruption, and BTB permeability modulation, which was developed in our laboratory. RESULTS Using immunolocalization, immunoblotting, and… CONTINUE READING
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