Modulation of brain hemichannels and gap junction channels by pro-inflammatory agents and their possible role in neurodegeneration.


In normal brain, neurons, astrocytes, and oligodendrocytes, the most abundant and active cells express pannexins and connexins, protein subunits of two families forming membrane channels. Most available evidence indicates that in mammals endogenously expressed pannexins form only hemichannels and connexins form both gap junction channels and hemichannels… (More)
DOI: 10.1089/ars.2008.2130