Modulation of brain-derived neurotrophic factor as a potential neuroprotective mechanism of action of omega-3 fatty acids in a parkinsonian animal model.

@article{Bousquet2009ModulationOB,
  title={Modulation of brain-derived neurotrophic factor as a potential neuroprotective mechanism of action of omega-3 fatty acids in a parkinsonian animal model.},
  author={M{\'e}lanie Bousquet and Claire Gibrat and Martine Saint-Pierre and Carl Julien and Fr{\'e}d{\'e}ric Calon and Francesca Cicchetti},
  journal={Progress in neuro-psychopharmacology & biological psychiatry},
  year={2009},
  volume={33 8},
  pages={1401-8}
}
While we recently reported the beneficial effects of omega-3 polyunsaturated fatty acids (n-3 PUFAs) in a mouse model of Parkinson's disease (PD), the mechanisms of action remain largely unknown. Here, we specifically investigated the contribution of the brain-derived neurotrophic factor (BDNF) to the neuroprotective effect of n-3 PUFA observed in a mouse model of PD generated by a subacute exposure to MPTP using a total of 7 doses of 20mg/kg over 5 days. The ten-month high n-3 PUFA treatment… CONTINUE READING