Modulation of both cisplatin nephrotoxicity and drug resistance in murine bladder tumor by controlling metallothionein synthesis.

@article{Satoh1993ModulationOB,
  title={Modulation of both cisplatin nephrotoxicity and drug resistance in murine bladder tumor by controlling metallothionein synthesis.},
  author={Masahiko Satoh and D. M. Kloth and Salam Kadhim and Joseph L. Chin and Akira Naganuma and Nobumasa Imura and M. George Cherian},
  journal={Cancer research},
  year={1993},
  volume={53 8},
  pages={1829-32}
}
The role of metallothionein (MT) in cisplatin (cis-DDP) resistance and renal toxicity was investigated in C3H mice inoculated with mouse bladder tumor (MBT-2). C3H mice were inoculated s.c. with 1 x 10(6) MBT-2 cells/mouse on day 0. Mice were given injections of proparglyglycine (PPG) (500 mumol/kg s.c.) once a day for 3 days from day 7 to day 9 and with ZnSO4 (200 mumol/kg s.c.) once a day for 2 days from day 8 to day 9. cis-DDP (50 mumol/kg i.p.) was administered 10 days after MBT-2 cell… CONTINUE READING

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Kinetic study on the reaction of cisplatin with metallothionein.

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