Modulation of beta-amyloid precursor protein processing and tau phosphorylation by acetylcholine receptors.

@article{HellstrmLindahl2000ModulationOB,
  title={Modulation of beta-amyloid precursor protein processing and tau phosphorylation by acetylcholine receptors.},
  author={Ewa Hellstr{\"o}m-Lindahl},
  journal={European journal of pharmacology},
  year={2000},
  volume={393 1-3},
  pages={255-63}
}
Neurofibrillary lesions and senile plaques that are composed mainly of hyperphosphorylated tau protein and the amyloid-beta peptide derived from the amyloid precursor protein, respectively, are classical hallmarks of Alzheimer's disease. A number of studies strongly suggests that amyloid-beta formation and amyloid depositions are linked to the pathogenesis of Alzheimer's disease. Recent findings suggest that very low concentrations of the amyloid-beta can inhibit various cholinergic… CONTINUE READING

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