Modulation of behavior and NMDA-R1 gene mRNA expression in adult female mice after sub-acute administration of benzo(a)pyrene.

@article{Grova2007ModulationOB,
  title={Modulation of behavior and NMDA-R1 gene mRNA expression in adult female mice after sub-acute administration of benzo(a)pyrene.},
  author={Nathalie Grova and Anne Valley and Jonathan D Turner and Andr{\'e}e Morel and Claude P. Muller and Henri Schroeder},
  journal={Neurotoxicology},
  year={2007},
  volume={28 3},
  pages={630-6}
}
The behavioral performances of adult mice exposed to sub-acute doses of benzo(a)pyrene (B(a)P) were monitored in tests related to learning and memory (Y maze and Morris water maze), locomotor activity (open-field test) and motor coordination (Locotronic apparatus). At low doses (0.02 and 0.2mg/kg), B(a)P impaired short-term learning and spatial memory performance in the Y maze and in the Morris water maze tests. Surprisingly, in the Y maze, the performances of animals exposed to the highest… CONTINUE READING

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