Modulation of bcl-2 and p27 in human primitive proliferating hematopoietic progenitors by autocrine TGF-beta1 is a cell cycle-independent effect and influences their hematopoietic potential.

@article{Pierelli2000ModulationOB,
  title={Modulation of bcl-2 and p27 in human primitive proliferating hematopoietic progenitors by autocrine TGF-beta1 is a cell cycle-independent effect and influences their hematopoietic potential.},
  author={Luca Pierelli and Maria Marone and Giuseppina Bonanno and Simona Mozzetti and Sergio Rutella and Roberta Morosetti and Carlo Rumi and Salvatore Mancuso and Giuseppe Leone and Giovanni Scambia},
  journal={Blood},
  year={2000},
  volume={95 10},
  pages={3001-9}
}
Primitive, proliferating hematopoietic progenitors (defined as cytokine low-responding primitive progenitors; CLRPP), isolated from human CD34+ cells, expressed endoglin (CD105) and produced transforming growth factor-beta1 (TGF-beta1). Culture of CLRPP in serum-free conditions with anti-TGF-beta1 monoclonal antibody produced a substantial decrease in bcl-2 protein/RNA levels and a significant reduction of cloning and long-term culture-initiating cell (LTC-IC) activities. GATA-1 and PU.1 RNA… CONTINUE READING

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