Modulation of basal and squamous cell carcinoma by endogenous estrogen in mouse models of skin cancer.

@article{Mancuso2009ModulationOB,
  title={Modulation of basal and squamous cell carcinoma by endogenous estrogen in mouse models of skin cancer.},
  author={Mariateresa Mancuso and Daniela Gallo and Simona Leonardi and Maria Pierdomenico and Emanuela Pasquali and Ilaria De Stefano and Simonetta Rebessi and Mirella Tanori and Giovanni Scambia and Vincenzo di Majo and Vincenzo Covelli and Simonetta Pazzaglia and Anna Saran},
  journal={Carcinogenesis},
  year={2009},
  volume={30 2},
  pages={340-7}
}
Patched1 heterozygous mice (Ptch1(+/-)) are useful for basal cell carcinoma (BCC) studies, being remarkably susceptible to BCC induction by ultraviolet or ionizing radiation. Analogously, skin carcinogenesis-susceptible (Car-S) mice are elective for studies of papilloma and squamous cell carcinoma (SCC) induction. We previously reported a striking effect of gender on BCC induction in Ptch1(+/-) mice, with total resistance of females; likewise, Car-S females show increased skin tumor resistance… CONTINUE READING

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