Modulation of aqueous humor outflow facility by the Rho kinase-specific inhibitor Y-27632.

  title={Modulation of aqueous humor outflow facility by the Rho kinase-specific inhibitor Y-27632.},
  author={Ponugoti Vasantha Rao and Peng Deng and Janardan Kumar and David Lee Epstein},
  journal={Investigative ophthalmology & visual science},
  volume={42 5},
PURPOSE The goal of this study was to investigate the role of Rho kinase in the modulation of aqueous humor outflow facility. Rho kinase, a critical downstream effector of Rho GTPase is recognized to control the formation of actin stress fibers, focal adhesions, and cellular contraction. METHODS Expression of Rho GTPase, Rho kinase, and other downstream targets of Rho GTPase were determined in human trabecular meshwork (HTM) and Schlemm's canal (SC) primary cell cultures by Western blot… CONTINUE READING
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Publications referenced by this paper.
Showing 1-10 of 45 references

Mechanism and routes of aqueous humor drainage

M Johnson, K. Erickson
Lakobiec FA, eds. Principles and Practice of Ophthalmology • 2000

The regulation of trabecular meshwork and ciliary muscle contractility

M Wiederholt, H Thieme, F. Stumff
Prog Retinal Eye Res • 2000
View 2 Excerpts

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