Modulation of appetite by gonadal steroid hormones

@article{Asarian2006ModulationOA,
  title={Modulation of appetite by gonadal steroid hormones},
  author={Lori Asarian and Nori Geary},
  journal={Philosophical Transactions of the Royal Society B: Biological Sciences},
  year={2006},
  volume={361},
  pages={1251 - 1263}
}
  • L. Asarian, N. Geary
  • Published 29 July 2006
  • Biology, Medicine
  • Philosophical Transactions of the Royal Society B: Biological Sciences
Several sex differences in eating, their control by gonadal steroid hormones and their peripheral and central mediating mechanisms are reviewed. Adult female rats and mice as well as women eat less during the peri-ovulatory phase of the ovarian cycle (estrus in rats and mice) than other phases, an effect under the control of cyclic changes in estradiol secretion. Women also appear to eat more sweets during the luteal phase of the cycle than other phases, possibly due to simultaneous increases… 

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References

SHOWING 1-10 OF 164 REFERENCES
Gonadal hormones and behavioral regulation of body weight.
  • G. Wade
  • Biology, Psychology
    Physiology & behavior
  • 1972
Gonadal steroids and energy homeostasis in the leptin era.
Sex differences in body weight and eating: organization and activation by gonadal hormones in the rat.
Some effects of ovarian hormones on food intake and body weight in female rats.
  • G. Wade
  • Biology
    Journal of comparative and physiological psychology
  • 1975
TLDR
Estradiol-treated ovariectomized rats are far more responsive to the weight- and appetite-promoting actions of progesterone than are ovariECTomized-adrenalectomization rats, suggesting that the principal action of progestersone on energy balance may be to interfere with the effects of estradiol.
Cyclic Estradiol Treatment Normalizes Body Weight and Restores Physiological Patterns of Spontaneous Feeding and Sexual Receptivity in Ovariectomized Rats
TLDR
These results provide the first demonstration that the induction of a cyclic, near-physiological pattern of plasma estradiol is sufficient to maintain normal levels of body weight, spontaneous feeding patterns, total food intake, and (together with progesterone) sexual receptivity in ovariectomized rats.
Sex differences in sensitivity of food intake, body weight, and running-wheel activity to ovarian steroids in rats.
  • R. T. Gentry, G. Wade
  • Biology, Psychology
    Journal of comparative and physiological psychology
  • 1976
TLDR
The effects of sex and experimental androgenization on the responsiveness of food intake and running-wheel activity to exogenously administered ovarian hormones were investigated in adult, gonadectomized rats and there was a positive correlation between the magnitude of the responses to EB and P.
Gonadal steroids and hypothalamic galanin and neuropeptide Y: role in eating behavior and body weight control in female rats.
TLDR
Evidence suggests that in the female rat, both GAL and NPY in the MPOA may contribute to the overeating and increased weight gain that occur during a fat-rich diet.
Leptin and the Hypothalamic-Pituitary Regulation of the Gonadotropin-Gonadal Axis
TLDR
Accumulating evidence suggests that leptin can regulate gonadotropin levels, and its secretion may, in turn, be influenced by GnRH or gonadal steroids but appears to be independent of LH control.
Estradiol increases glucagon's satiating potency in ovariectomized rats.
  • N. Geary, L. Asarian
  • Biology, Medicine
    American journal of physiology. Regulatory, integrative and comparative physiology
  • 2001
TLDR
Data indicate that an increase in the activity of the endogenous glucagon satiation-signaling pathway may be part of the mechanism for estradiol's inhibitory effect on feeding.
Estradiol-Dependent Decrease in the Orexigenic Potency of Ghrelin in Female Rats
TLDR
It is suggested that estradiol inhibits the orexigenic action of ghrelin in females, that weight gain associated with OVX is gh Relin mediated, and that this endocrine interaction may account for an important sex differences in food intake and the regulation of body weight.
...
...