Modulation of apoptotic cell death by extracellular matrix proteins and a fibronectin-derived antiadhesive peptide.

@article{Fukai1998ModulationOA,
  title={Modulation of apoptotic cell death by extracellular matrix proteins and a fibronectin-derived antiadhesive peptide.},
  author={Fumio Fukai and Masayuki Mashimo and Koichi Akiyama and Tetsuhisa Goto and Sei-ichi Tanuma and Takashi Katayama},
  journal={Experimental cell research},
  year={1998},
  volume={242 1},
  pages={92-9}
}
Cell adhesion to the extracellular matrix (ECM) has been implicated in apoptosis in anchorage-dependent cell types. We recently found that a peptide derived from fibronectin (termed III14-2) inhibits the integrin-mediated cell adhesion to ECM. Using this antiadhesive peptide and a variety of ECM proteins, we show here a critical role of the integrin-ECM protein interaction in apoptotic regulation of human umbilical vein endothelial cells (HUVEC). HUVEC in suspension underwent apoptosis under… CONTINUE READING

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