Modulation of apoptosis in intestinal lymphocytes by a probiotic bacteria in Crohn's disease.

@article{Carol2006ModulationOA,
  title={Modulation of apoptosis in intestinal lymphocytes by a probiotic bacteria in Crohn's disease.},
  author={M Robinson Carol and Natalia Borruel and Mar{\'i}a Jos{\'e} Paz Antol{\'i}n and Marta Valledor Llopis and Francesc Casellas and Francisco Guarner and Juan-R Malagelada},
  journal={Journal of leukocyte biology},
  year={2006},
  volume={79 5},
  pages={
          917-22
        }
}
Apoptosis of active T lymphocytes constitutes a major control mechanism of immune homeostasis and tolerance. In Crohn's disease, abnormal activation of mucosal T lymphocytes against enteric bacteria is the key event triggering intestinal inflammation. Resistance of lymphocytes to apoptosis has been proposed as the pathogenetic defect. We examined the influence of bacteria-mucosa interactions on apoptosis of mucosal T lymphocytes. Ileal specimens were obtained at surgery from 12 patients with… CONTINUE READING
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