Modulation of apoptosis by cigarette smoke and cancer chemopreventive agents in the respiratory tract of rats.

@article{DAgostini2001ModulationOA,
  title={Modulation of apoptosis by cigarette smoke and cancer chemopreventive agents in the respiratory tract of rats.},
  author={Francesco D'Agostini and Roumen M Balansky and Alberto Izzotti and Ronald A. Lubet and Gary j. Kelloff and Silvio De Flora},
  journal={Carcinogenesis},
  year={2001},
  volume={22 3},
  pages={
          375-80
        }
}
Preclinical studies may elucidate the meaning of biomarkers applicable to epidemiologic studies and to clinical trials for cancer prevention. No study has explored so far the effect of cigarette smoke on apoptosis in vivo. We evaluated modulation of apoptosis in cells of the respiratory tract of smoke-exposed Sprague-Dawley rats both by morphological analysis and TUNEL method. In a first study, exposure of rats to mainstream cigarette smoke for either 18 or 100 consecutive days produced a… 

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