Modulation of apolipoprotein D and apolipoprotein E mRNA expression by growth arrest and identification of key elements in the promoter.

@article{Carmo2002ModulationOA,
  title={Modulation of apolipoprotein D and apolipoprotein E mRNA expression by growth arrest and identification of key elements in the promoter.},
  author={Sonia Do Carmo and Diane S{\'e}guin and Ross Milne and {\'E}ric Rassart},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 7},
  pages={5514-23}
}
Apolipoprotein D (apoD) and apolipoprotein E (apoE) are co-expressed in many tissues, and, in certain neuropathological situations, their expression appears to be under coordinate regulation. We have previously shown that apoD gene expression in cultured human fibroblasts is up-regulated when the cells undergo growth arrest. Here, we demonstrate that, starting around day 2 of growth arrest, both apoD and apoE mRNA levels increase between 1.5- and 27-fold in other cell types, including mouse… CONTINUE READING