Modulation of antigen presenting cell functions during chronic HPV infection

  title={Modulation of antigen presenting cell functions during chronic HPV infection},
  author={Abate Assefa Bashaw and Graham R Leggatt and Janin Chandra and Zewen Kelvin Tuong and Ian H Frazer},
  booktitle={Papillomavirus research},
High-risk human papillomaviruses (HR-HPV) infect basal keratinocytes, where in some individuals they evade host immune responses and persist. Persistent HR-HPV infection of the cervix causes precancerous neoplasia that can eventuate in cervical cancer. Dendritic cells (DCs) are efficient in priming/cross-priming antigen-specific T cells and generating antiviral and antitumor cytotoxic CD8+ T cells. However, HR-HPV have adopted various immunosuppressive strategies, with modulation of DC function… CONTINUE READING


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