Modulation of antibody display on M13 filamentous phage.

@article{Chappel1998ModulationOA,
  title={Modulation of antibody display on M13 filamentous phage.},
  author={Jonathan A Chappel and Mingyue He and Angray S. Kang},
  journal={Journal of immunological methods},
  year={1998},
  volume={221 1-2},
  pages={
          25-34
        }
}
Here we describe a phage vector for the display of single chain antibodies and polypeptides on the surface of filamentous M13 phage which permits facile manipulation of the valency of display. The gene encoding the polypeptide is fused to a synthetic copy of the major coat protein VIII gene (gpVIII) which permits incorporation into the phage during assembly of the filament. Here we examine the growth parameters of phage propagation on the subsequent selection of an anti-progesterone antibody… CONTINUE READING
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