Modulation of angiotensin II-mediated cardiac remodeling by the MEF2A target gene Xirp2.

@article{McCalmon2010ModulationOA,
  title={Modulation of angiotensin II-mediated cardiac remodeling by the MEF2A target gene Xirp2.},
  author={Sarah A McCalmon and Danielle M. Desjardins and Saad Ahmad and Katharine S. Davidoff and Christine M Snyder and Kaori Sato and Koji Ohashi and Ondra M Kielbasa and Matthen Mathew and Elizabeth P. Ewen and Kenneth Walsh and Haralambos Gavras and Francisco J Naya},
  journal={Circulation research},
  year={2010},
  volume={106 5},
  pages={952-60}
}
RATIONALE The vasoactive peptide angiotensin II (Ang II) is a potent cardiotoxic hormone whose actions have been well studied, yet questions remain pertaining to the downstream factors that mediate its effects in cardiomyocytes. OBJECTIVE The in vivo role of the myocyte enhancer factor (MEF)2A target gene Xirp2 in Ang II-mediated cardiac remodeling was investigated. METHODS AND RESULTS Here we demonstrate that the MEF2A target gene Xirp2 (also known as cardiomyopathy associated gene 3… CONTINUE READING
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