Modulation of an acetylcholine receptor responsiveness by filipin and chlorpromazine studied in neurons ofAplysia californica

Abstract

1. The responsiveness ofAplysia acetylcholine receptors (AChR) was studied using a polyene antibiotic, filipin, which specifically complexes cholesterol, and another compound, chlorpromazine (CPZ), which inserts at the proteolipidic interface. 2. Both substances enhanced the evoked postsynaptic responses or responses to iontophoretic application of… (More)
DOI: 10.1007/BF00734989

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