Modulation of amyloid precursor protein metabolism by X11α/MINT-1. A deletion analysis of protein-protein interaction domains

@article{Mueller2000ModulationOA,
  title={Modulation of amyloid precursor protein metabolism by X11α/MINT-1. A deletion analysis of protein-protein interaction domains},
  author={Helena T Mueller and Jean-Paul Borg and Ben L Margolis and Raymond Scott Turner},
  journal={Neurobiology of Aging},
  year={2000},
  volume={21}
}
Modulation of amyloid precursor protein (APP) metabolism plays a pivotal role in the pathogenesis of Alzheimer's disease. The phosphotyrosine-binding/protein interaction (PTB/PI) domain of X11alpha, a neuronal cytosolic adaptor protein, binds to the YENPTY sequence in the cytoplasmic carboxyl terminus of APP. This interaction prolongs the half-life of APP and inhibits Abeta40 and Abeta42 secretion. X11alpha/Mint-1 has multiple protein-protein interaction domains, a Munc-18 interaction domain… CONTINUE READING

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