Modulation of albumin secretion by ornithine alpha-ketoglutarate in adult rat hepatocyte cultures and a human hepatoma cell line (HepG2).

@article{Lescoat1989ModulationOA,
  title={Modulation of albumin secretion by ornithine alpha-ketoglutarate in adult rat hepatocyte cultures and a human hepatoma cell line (HepG2).},
  author={G. Lescoat and B. Desvergne and O. Lor{\'e}al and N. Pasdeloup and Y. Deugnier and M. Bourel and P. Brissot},
  journal={Annals of nutrition \& metabolism},
  year={1989},
  volume={33 5},
  pages={
          252-60
        }
}
Cocultured adult rat hepatocytes and a human hepatoma cell line (HepG2) were maintained in an arginine-free medium with or without ornithine alpha-ketoglutarate. This drug increased greatly hepatocyte albumin secretion in both culture models. L-Ornithine was the component accounting for these effects since similar data were obtained by using this sole amino acid. Moreover, we observed that L-ornithine stimulation of albumin production was via polyamine synthesis. Since a correlated increase in… Expand
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