Modulation of airway hyperresponsiveness and eosinophilia by selective histamine and 5-HT receptor antagonists in a mouse model of allergic asthma.

@article{Bie1998ModulationOA,
  title={Modulation of airway hyperresponsiveness and eosinophilia by selective histamine and 5-HT receptor antagonists in a mouse model of allergic asthma.},
  author={Joris J de Bie and P A J Henricks and William W. Cruikshank and Gerard A. Hofman and E H Jonker and Frans P. Nijkamp and Antoon J M van Oosterhout},
  journal={British journal of pharmacology},
  year={1998},
  volume={124 5},
  pages={857-64}
}
1. Since both histamine and 5-hydroxytryptamine (5-HT) can be released by murine mast cells, we investigated the possible role of these autacoids on airway hyperresponsiveness (AHR), eosinophil infiltration and serum-IgE levels in a murine model of allergic asthma. 2. Ovalbumin-sensitized mice were exposed to either ovalbumin (2 mg ml(-1)) or saline aerosols on 8 consecutive days. Starting one day before the challenge, animals were injected i.p. twice a day with a 5-HT-type 1 (5-HT1) or type 2… CONTINUE READING

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