Modulation of agmatine on calcium signal in morphine-dependent CHO cells by activation of IRAS, a candidate for imidazoline I1 receptor.

@article{Wu2006ModulationOA,
  title={Modulation of agmatine on calcium signal in morphine-dependent CHO cells by activation of IRAS, a candidate for imidazoline I1 receptor.},
  author={Ning Wu and Rui-bin Su and Yin Liu and Xin-qiang Lu and Jian-quan Zheng and B. H. Cong and Jin Li},
  journal={European journal of pharmacology},
  year={2006},
  volume={548 1-3},
  pages={21-8}
}
The present study investigated the effects of agmatine action on imidazoline I1 receptor antisera-selected protein (IRAS), a candidate for imidazoline I1 receptor, on prolonged morphine-induced adaptations of calcium signal and long-lasting alterations in gene expression to further elucidate the role of IRAS in opioid dependence. Two cell lines, Chinese hamster ovary cells expressing mu opioid receptor alone (CHO-mu) and expressing mu opioid receptor and IRAS together (CHO-mu/IRAS), were used… CONTINUE READING

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