Modulation of aged murine T lymphocytes in vivo by DPV576-C, a nanodiamond- and nanoplatinum-coated material.

Abstract

BACKGROUND Nanotechnology is rapidly emerging in biomedical applications, including cancer therapy. Here, a mixture of ultra dispersed nanodiamond and nanoplatinum was coated onto fabrics in the form of a cloth (DPV576-C). The role of DPV576-C in modulating T lymphocytes of aged mice was examined. MATERIALS AND METHODS C57BL/6 mice were treated with DPV576-C as a lining in a mouse house for 1 month. Splenic cells were analyzed for CD4(+) and CD8(+) T-cells and NK activity using flow cytometry. RESULTS DPV576-C-treated aged mice showed an: (1) increase in the percentages of CD4(+) and CD8(+) T-cells and their activation markers, CD25 and CD69, over untreated aged mice; (2) enhancement of NK activity; and (3) absence of adverse side effects as determined histopathologically. CONCLUSION The enhancement of lymphocytes by DPV576-C may be useful for patients suffering from immune dysfunction.

Cite this paper

@article{Ghoneum2010ModulationOA, title={Modulation of aged murine T lymphocytes in vivo by DPV576-C, a nanodiamond- and nanoplatinum-coated material.}, author={Mamdooh H. Ghoneum and Alia Ghoneum and Lucilene F Tolentino and James K. Gimzewski}, journal={In vivo}, year={2010}, volume={24 2}, pages={141-6} }