Modulation of age at onset in Huntington's disease and spinocerebellar ataxia type 2 patients originated from eastern India.

@article{Chattopadhyay2003ModulationOA,
  title={Modulation of age at onset in Huntington's disease and spinocerebellar ataxia type 2 patients originated from eastern India.},
  author={Biswanath Chattopadhyay and Subho Ghosh and Prasanta Kumar Gangopadhyay and Shaymal K Das and Tilottama Roy and Krishna K. Sinha and Dilip Kumar Jha and Subhash Chandra Mukherjee and Ambar Chakraborty and Bhim Sen Singhal and Anup Kr Bhattacharya and Nitai P. Bhattacharyya},
  journal={Neuroscience letters},
  year={2003},
  volume={345 2},
  pages={93-6}
}
To identify the genetic modifier(s) that might alter the age at onset in Huntington's disease (HD) we have analyzed variations in GluR6 kainate receptor (GluR6), CA150 gene, Delta2642 and polymorphic CCG repeat variation in huntingtin (htt) gene in 77 HD patients and normal individuals. In addition, variation in the RAI1 gene was analyzed in 30 spinocerebellar ataxia (SCA2) patients and normal individuals to show the possible influence on the age at onset. Multiple regression analysis indicated… CONTINUE READING