Modulation of adipokine production, glucose uptake and lactate release in human adipocytes by small changes in oxygen tension

@article{Wood2011ModulationOA,
  title={Modulation of adipokine production, glucose uptake and lactate release in human adipocytes by small changes in oxygen tension},
  author={Irmgard S. Wood and Tanya Stezhka and Paul Trayhurn},
  journal={Pfl{\"u}gers Archiv - European Journal of Physiology},
  year={2011},
  volume={462},
  pages={469-477}
}
Adipose tissue becomes hypoxic in obesity, and cell culture studies have demonstrated that hypoxia leads to major changes in adipocyte function. Studies on the response of adipocytes to low O2 tension have employed marked hypoxia (1% O2). Here, we have examined the effects of modest hypoxia, utilising differing concentrations of O2 (1–21%), on adipokine production and glucose uptake by human adipocytes. Incubation with 10% O2 (24 h) increased expression of the leptin, vascular endothelial… CONTINUE READING

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