Modulation of adenosine A1 and A2A receptors in C6 glioma cells during hypoxia: involvement of endogenous adenosine.

@article{Castillo2008ModulationOA,
  title={Modulation of adenosine A1 and A2A receptors in C6 glioma cells during hypoxia: involvement of endogenous adenosine.},
  author={Carlos Alberto Castillo and David Agust{\'i}n Le{\'o}n and Mar{\'i}a {\'A}ngeles Ruiz and J L Albasanz and Mairena Mart{\'i}n},
  journal={Journal of neurochemistry},
  year={2008},
  volume={105 6},
  pages={2315-29}
}
During hypoxia, extracellular adenosine levels are increased to prevent cell damage, playing a neuroprotective role mainly through adenosine A(1) receptors. The aim of the present study was to analyze the effect of hypoxia in both adenosine A(1) and A(2A) receptors endogenously expressed in C6 glioma cells. Two hours of hypoxia (5% O(2)) caused a significant decrease in adenosine A(1) receptors. The same effect was observed at 6 h and 24 h of hypoxia. However, adenosine A(2A) receptors were… CONTINUE READING
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