Modulation of adaptive immunity by different adjuvant-antigen combinations in mice lacking Nod2.

@article{Moreira2008ModulationOA,
  title={Modulation of adaptive immunity by different adjuvant-antigen combinations in mice lacking Nod2.},
  author={L{\'i}lian Oliveira Moreira and Amber M. Smith and Ashley A DeFreitas and Joseph E. Qualls and Karim C El Kasmi and Peter J Murray},
  journal={Vaccine},
  year={2008},
  volume={26 46},
  pages={5808-13}
}
The mechanisms underlying adjuvant effects are under renewed scrutiny because of the enormous implications for vaccine development. Additionally, new low-toxicity adjuvants are sought to enhance vaccine formulations. Muramyl dipeptide (MDP) is a component of the peptidoglycan polymer and was shown to be an active but low-toxicity component of complete Freund's adjuvant, a powerful adjuvant composed of mycobacteria lysates in an oil emulsion. MDP activates cells primarily via the cytosolic NLR… CONTINUE READING

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