Modulation of activator protein-1 (AP-1) and MAPK pathway by flavonoids in human prostate cancer PC3 cells.

@article{Gopalakrishnan2006ModulationOA,
  title={Modulation of activator protein-1 (AP-1) and MAPK pathway by flavonoids in human prostate cancer PC3 cells.},
  author={Avanthika Gopalakrishnan and Chang-jiang Xu and Sujit S. Nair and Chi Wei Chen and Vidya Hebbar and A N Tony Kong},
  journal={Archives of pharmacal research},
  year={2006},
  volume={29 8},
  pages={
          633-44
        }
}
In last couple of decades the use of natural compounds like flavonoids as chemopreventive agents has gained much attention. Our current study focuses on identifying chemopreventive flavonoids and their mechanism of action on human prostate cancer cells. Human prostate cancer cells (PC3), stably transfected with activator protein 1 (AP-1) luciferase reporter gene were treated with four main classes of flavonoids namely flavonols, flavones, flavonones, and isoflavones. The maximum AP-1 luciferase… CONTINUE READING
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