Modulation of action potential by [Ca2+]i in modeled rat atrial and guinea pig ventricular myocytes.

@article{Han2002ModulationOA,
  title={Modulation of action potential by [Ca2+]i in modeled rat atrial and guinea pig ventricular myocytes.},
  author={Chunlei Han and Pasi Tavi and Matti Weckstr{\"o}m},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2002},
  volume={282 3},
  pages={H1047-54}
}
We simulated mechanisms that increase Ca2+ transients with two models: the Luo-Rudy II model for guinea pig (GP) ventricle (GP model) representing long action potential (AP) myocytes and the rat atrial (RA) model exemplifying myocytes with short APs. The interventions were activation of stretch-gated cationic channels, increase of intracellular Na+ concentration ([Na+]i), simulated bet-adrenoceptor stimulation, and Ca2+ accumulation into the sarcoplasmic reticulum (SR). In the RA model… CONTINUE READING

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3 Excerpts

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