Modulation of acid-sensing ion channel activity by nitric oxide.

  title={Modulation of acid-sensing ion channel activity by nitric oxide.},
  author={Herv{\'e} Cadiou and Milena Studer and Nicholas G. Jones and Ewan St John Smith and Angela M Ballard and Stephen B. McMahon and Peter A McNaughton},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={27 48},
Acid-sensing ion channels (ASICs) are a class of ion channels activated by extracellular protons and are believed to mediate the pain caused by tissue acidosis. Although ASICs have been widely studied, little is known about their regulation by inflammatory mediators. Here, we provide evidence that nitric oxide (NO) potentiates the activity of ASICs. Whole-cell patch-clamp recordings were performed on neonatal rat cultured dorsal root ganglion neurons and on ASIC isoforms expressed in CHO cells… CONTINUE READING
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