Modulation of Voltage-Dependent and Inward Rectifier Potassium Channels by 15-Epi-Lipoxin-A4 in Activated Murine Macrophages: Implications in Innate Immunity

@article{Moreno2013ModulationOV,
  title={Modulation of Voltage-Dependent and Inward Rectifier Potassium Channels by 15-Epi-Lipoxin-A4 in Activated Murine Macrophages: Implications in Innate Immunity},
  author={Cristina Moreno and P. Prieto and A. Macias and M. Pimentel-Santillana and Alicia de la Cruz and P. Trav{\'e}s and L. Bosc{\'a} and C. Valenzuela},
  journal={The Journal of Immunology},
  year={2013},
  volume={191},
  pages={6136 - 6146}
}
Potassium channels modulate macrophage physiology. Blockade of voltage-dependent potassium channels (Kv) by specific antagonists decreases macrophage cytokine production and inhibits proliferation. In the presence of aspirin, acetylated cyclooxygenase-2 loses the activity required to synthesize PGs but maintains the oxygenase activity to produce 15R-HETE from arachidonate. This intermediate product is transformed via 5-LOX into epimeric lipoxins, termed 15-epi-lipoxins (15-epi-lipoxin A4 [e… Expand
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References

SHOWING 1-10 OF 66 REFERENCES
Immunomodulation of voltage-dependent K+ channels in macrophages: molecular and biophysical consequences
TLDR
It is demonstrated that the biophysical properties of voltage-dependent K+ currents are modified upon activation or immunosuppression in macrophages, in accordance with changes in the molecular characteristics of the heterotetrameric Kv1.3/KV1.5 hybrid channel. Expand
Association of Kv1.5 and Kv1.3 Contributes to the Major Voltage-dependent K+ Channel in Macrophages*
TLDR
Results demonstrate that Kv1.5 co-associates with KV1.3, generating functional heterotetramers in macrophages, which is consistent with a hyperpolarized shift in half-activation voltage and a lower IC50 for margatoxin. Expand
Differential Voltage-dependent K+ Channel Responses during Proliferation and Activation in Macrophages*
TLDR
The results demonstrate that the differential regulation of VDPC is crucial in intracellular signals determining the specific macrophage response. Expand
Lipoxin A4 impairment of apoptotic signaling in macrophages: implication of the PI3K/Akt and the ERK/Nrf-2 defense pathways
TLDR
Treatment of human or murine macrophages with LXA4 significantly inhibits the apoptosis induced by staurosporine, etoposide and S-nitrosoglutathione or by more pathophysiological stimuli, such as LPS/IFNγ challenge. Expand
A vasculo-protective circuit centered on lipoxin A4 and aspirin-triggered 15-epi-lipoxin A4 operative in murine microcirculation.
TLDR
It is proposed that during ischemia, neutrophil Fpr2/3 controls platelet/neutrophil aggregates with the rapid generation of circulating LXA4, which in turn modulates downstream vascular inflammatory responses evident during the reperfusion phase. Expand
Selective Impairment of P2Y Signaling by Prostaglandin E2 in Macrophages: Implications for Ca2+-Dependent Responses
TLDR
The inhibition of P2y signaling by PGE2 has an impact on the cell migration elicited by P2Y agonists in thioglycollate-elicited and alternatively activated macrophages, which provide new clues to understand the resolution phase of inflammation, when accumulation of PGE 2, anti-inflammatory and proresolving mediators occurs. Expand
Activation of Natural Killer T Cells Ameliorates Postinfarct Cardiac Remodeling and Failure in Mice
TLDR
iNKT cells play a protective role against post-MI LV remodeling and failure through the enhanced expression of cardioprotective cytokines such as IL-10. Expand
High-sensitivity C-reactive protein, statin therapy, and risks of atrial fibrillation: an exploratory analysis of the JUPITER trial.
TLDR
Within the JUPITER trial cohort of individuals selected for underlying inflammation, increasing levels of high-sensitivity C-reactive protein were associated with an increased risk of incident AF and random allocation to rosuvastatin significantly reduced that risk. Expand
Macrophage proresolving mediator maresin 1 stimulates tissue regeneration and controls pain
  • C. Serhan, J. Dalli, +6 authors N. Petasis
  • Biology, Medicine
  • FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 2012
TLDR
It is determined that maresin 1 (MaR1) produced by human MΦs from endogenous docosahexaenoic acid (DHA) matched synthetic 7R,14S‐dihydroxydocosa‐4Z,8E,10E,12Z,16Z,19Z‐hexaenosic acid, suggesting that chemical signals are shared in resolution cellular trafficking, a key process in tissue regeneration. Expand
PKC activity regulates functional effects of KVb1.3 on KV1.5 channels. Identification of a cardiac KV1.5 channelosome
  • J. Biol
  • 2012
...
1
2
3
4
5
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