Modulation of Visceral Nociception, Inflammation and Gastric Mucosal Injury by Cinnarizine

  title={Modulation of Visceral Nociception, Inflammation and Gastric Mucosal Injury by Cinnarizine},
  author={Omar M. E. Abdel-Salam},
  journal={Drug Target Insights},
  pages={29 - 38}
The effect of cinnarizine, a drug used for the treatment of vertigo was assessed in animal models of visceral nociception, inflammation and gastric mucosal injury. Cinnarizine (1.25–20 mg/kg, s.c.) caused dose-dependent inhibition of the abdominal constrictions evoked by i.p. injection of acetic acid by 38.7–99.4%. This effect of cinnarizine (2.5 mg/kg) was unaffected by co-administration of the centrally acting dopamine D2 receptor antagonists, sulpiride, haloperidol or metoclopramide, the… 
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  • 1990
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