Modulation of Visceral Nociception, Inflammation and Gastric Mucosal Injury by Cinnarizine

@article{AbdelSalam2007ModulationOV,
  title={Modulation of Visceral Nociception, Inflammation and Gastric Mucosal Injury by Cinnarizine},
  author={Omar M. E. Abdel-Salam},
  journal={Drug Target Insights},
  year={2007},
  volume={2},
  pages={29 - 38}
}
The effect of cinnarizine, a drug used for the treatment of vertigo was assessed in animal models of visceral nociception, inflammation and gastric mucosal injury. Cinnarizine (1.25–20 mg/kg, s.c.) caused dose-dependent inhibition of the abdominal constrictions evoked by i.p. injection of acetic acid by 38.7–99.4%. This effect of cinnarizine (2.5 mg/kg) was unaffected by co-administration of the centrally acting dopamine D2 receptor antagonists, sulpiride, haloperidol or metoclopramide, the… 
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References

SHOWING 1-10 OF 74 REFERENCES
Antinociceptive effect of meloxicam, in neurogenic and inflammatory nociceptive models in mice
TLDR
It is shown that meloxicam dose-dependently exhibited systemic antinociceptive action when assessed against neurogenic and inflammatory pain caused by acetic acid, formalin and capsaicin models.
Antinociceptive effects of calcium channel blockers in the rat.
  • E. M. Rego, A. Corrado, W. A. Prado
  • Chemistry, Medicine
    Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas
  • 1990
TLDR
It is concluded that the antinociception evoked by a systemically injected calcium channel blocker is dependent on passage of the drug across the blood brain barrier to act, at least in part, at a spinal site of action.
The antinociceptive effects of the systemic adenosine A1 receptor agonist CPA in the absence and in the presence of spinal cord sensitization
TLDR
It is concluded that systemic CPA is a potent and effective analgesic in sensitization due to arthritis and neuropathy but also in acute nociception.
Intrathecal baclofen and muscimol, but not midazolam, are antinociceptive using the rat-formalin model.
  • D. M. Dirig, T. Yaksh
  • Chemistry, Medicine
    The Journal of pharmacology and experimental therapeutics
  • 1995
TLDR
Both GABAA and GABAB agonists are antinociceptive at the spinal cord level and that endogenous spinal GABA levels are insufficient for a GABA potentiator to act alone in an antinOCiceptive manner.
Effects of dopaminergic agents on visceral pain measured by the mouse writhing test.
TLDR
The present results suggest an involvement of the dopaminergic transmission in visceral nociception in mouse writhing test analgesia, which appears to involve exclusively the central D2 receptor system, and does not seem to be influenced by opioid mechanisms.
Noradrenaline but not dopamine involved in NMDA receptor-mediated hyperalgesia induced by theophylline in awake rats.
  • G. Paalzow
  • Chemistry, Medicine
    European journal of pharmacology
  • 1994
Theophylline dose-dependently decreased a supraspinally integrated nociceptive threshold in awake rats. This hyperalgesia was antagonized by pretreatment with the N-methyl-D-aspartate (NMDA) receptor
The Interaction Between Gamma-Aminobutyric Acid Agonists and Diltiazem in Visceral Antinociception in Rats
TLDR
In conclusion, intrathecal diltiazemin combination with a GABA agonist, muscimol or baclofen, potentiated the GABA agonists-induced visceral antinociception without increasing motor paralysis.
Participation of the sympathetic system in acetic acid-induced writhing in mice.
  • I. Duarte, M. Nakamura, S. Ferreira
  • Chemistry, Medicine
    Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas
  • 1988
TLDR
Results are consistent with the suggestion of Nakamura and Ferreira (1) that inflammatory nociception has a dual component: one mediated by cyclooxygenase metabolites and another by sympathetic amines, possibly acting through a DA-1 type receptor.
Role of serotonergic and noradrenergic systems in a model of visceral pain.
TLDR
The results obtained with selective receptor ligands, DSP-4 and p-CPA, indicate that the noradrenergic and serotonergic innervation of the central nervous system contribute in a complex way to the animal behavior in the writhing test.
On the antinociceptive effect of fluoxetine, a selective serotonin reuptake inhibitor
TLDR
Data suggest that fluoxetine-induced antinociception involves both central opioid and the serotoninergic pathways, as well as the possible mechanism of a selective serotonin reuptake inhibitor (SSRI) fluoxettine- induced ant inociceptive effect in animals.
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