Modulation of Vigilance in the Primary Hypersomnias by Endogenous Enhancement of GABAA Receptors

@article{Rye2012ModulationOV,
  title={Modulation of Vigilance in the Primary Hypersomnias by Endogenous Enhancement of GABAA Receptors},
  author={David B. Rye and Donald L. Bliwise and Kathy P. Parker and Lynn Marie Trotti and Prabhjyot Saini and Jacqueline A. Fairley and Amanda A. H. Freeman and Paul S. Garc{\'i}a and Michael J. Owens and James C. Ritchie and Andrew Jenkins},
  journal={Science Translational Medicine},
  year={2012},
  volume={4},
  pages={161ra151 - 161ra151}
}
A component of cerebrospinal fluid in excessively sleepy people activates an inhibitory signaling pathway and mimics the actions of sedative-hypnotics. Awake and Refreshed A spindle prick on the finger, and Princess Aurora couldn’t keep her eyes open; one hundred years later, Sleeping Beauty was awakened with a kiss. But persistent daytime sleepiness—hypersomnolence—is no fairy tale, and neither the cause nor a cure is apparent. Now, Rye et al. begin to illuminate, in patients with primary… 
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Different CNS hypersomnias present with specific features of EDS are useful to guide the clinician to apply and interpret appropriate neurophysiological investigations.
Idiopathic hypersomnia.
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