Modulation of Tramadol Release from a Hydrophobic Matrix: Implications of Formulations and Processing Variables

  title={Modulation of Tramadol Release from a Hydrophobic Matrix: Implications of Formulations and Processing Variables},
  author={Borusu Sri Naga Sudha and B. K. Sridhar and Anegundha Srinatha},
  journal={AAPS PharmSciTech},
In the present investigation, hydrogenated cottonseed oil (HCSO) was evaluated as a sustained release matrix for a freely soluble drug, tramadol. Hydrophobic matrix tablets of tramadol, was evaluated by compression of physical mixture of drug and wax, dispersion of drug in HCSO by hot fusion or solubilisation techniques. The method of preparation of tablet had a significant effect on drug release with higher release observed from direct compression matrices and slower release from matrix… 

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